Endocrine Abstracts

Introduction: Diabetic ketoacidosis (DKA) is an endocrine emergency and the leading cause of morbi-mortality in children with type 1 diabetes mellitus (1DM). DKA treatment is still controverse, mainly regarding hydroelectrolytic replacement and insulin dose.Aims: To evaluate efectiveness and safety of our tertiary centre protocol in DKA treatment, which included initial volume expansion with isotonic saline in the first two hours followed by 0.45% sodium...

Estrogen-producing adrenal gland tumors (EPAGT) are extremely rare, accounting for only 1–2% of all adrenal tumors. They are most commonly observed in men or in children, and are unusual in women. They are almost always malignant even if they seem benign at presentation, and most of them have a poor prognosis. We present a case of a 71-year-old man with painful bilateral gynecomastia, without galactorrhea, over 4 months. Markedly elevated plasma estradiol levels were foun...

Introduction: Cushing’s syndrome (CS) is a rare disease resulting from prolonged exposure to supraphysiological levels of glucocorticoids. Cushing’s Disease is the most frequent cause of endogenous CS. This disease has a broad spectrum of clinical manifestations and is associated with an increased morbi-mortality. Diabetes Mellitus (DM) and hypokalemic alkalosis affects up to 50 and 10% of CS patients respectively. Disease onset and severity reflects the magnitude of...

Functional hypogonadism has been described in association with acute severe medical or surgical illness, subacute recovery and chronic disease. We present a case of transitory hypogonadism manifested during a peri-surgical period. A 42-year-old patient was sent to the endocrinology clinic due to hypertension and a solitary adrenal mass. He was treated with bisoprolol and telmisartan, that he maintains until today. The evaluation favoured non-functional adenoma but during the f...

Follicle-stimulating hormone (FSH) therapy is a potential treatment option in idiopathic infertile men with normal FSH levels. In fact, a recent Cochrane meta-analysis showed that FSH treatment of men affected by idiopathic oligozoospermia significantly improves pregnancy rate. Hyaluronic acid (HA) binding capacity of spermatozoa is considered a marker of functional competency, consequently the evaluation of the percentage of HA bound spermatozoa in the ejaculate can serve as ...

Background: Management of obesity and overweight greatly improves glycemic control in type 2 diabetic (T2DM) patients and also provides positive impact in other cardiovascular risk factors in this population.Objectives: Evaluate the impact of weight and weight variability in subclinical inflammation and comorbidities of T2DM patients, over the last decade.Methods: Retrospective study of 1900 patients with T2DM, with a minimum of 2 ...

Introduction: The ‘Atypia of Undetermined Significance/Follicular lesion of Undetermined Significance’ (AUS/FLUS) category of the Bethesda Classification for thyroid nodules fine needle aspiration cytology (FNAC) is reserved for specimens that contain cells with architectural and/or nuclear atypia that is not sufficient to be classified as suspicious or malignant. Our objective is to report our experience in the follow-up and outcome of patients with AUS/FLUS in thyr...

Introduction: Increasing incidence of thyroid cancer might be a consequence of an increase detection of subclinical disease. The aim of this study was to compare the clinical and pathologic characteristics of nonincidentally discovered (NID) thyroid cancer with incidentally discovered (ID) on postoperative pathology.Methods: A retrospective medical record review of 104 patients with thyroid cancer was performed. A group I of 69 patients with NID thyroid ...

Introduction: Obestatin has been proposed to have anorexigenic and anti-ghrelin action. An association has been found between ghrelin and its decline with ageing and muscle strength and functional capacity, probably mediated by GH–IGF1 axis. However, no information is available in relation to the role of obestatin in muscle strength and functional capacity.Objective: The objective was to study obestatin concentrations in relation to handgrip strengt...

Introduction: Leptin seems to be a major link between obesity and thyroid dysfunction.Design: To analyze the relationship between thyrotropin (TSH) and leptin (LP) plasma concentrations and body mass index (BMI), in 785 subjects (448 women) of 41.27±9.72 years and BMI 28.91±9.8 (18.04–93.98 kg/m2), without diagnosed thyroid disease or pregnancy, concentrations of TSH, free thyroxine (FT4), LP, glycemia and insulinemia...